From Tampa, I-275 South, crossing the Howard Frankland bridge. Continue South through St Petersburg. After you pay the toll for the Sunshine Skyway Bridge, you will start watching for your exit. You do not cross the Skyway bridge, but instead exit right before it. Turn left at the stop sign at the end of exit ramp and follow the road around to the beach.
Due to Homeland Security regulations there is a 300 yard distance restriction from the bridge which applies to watercraft, swimmers, divers, non motorized boats, kites, etc. Watch out for stone crab buoys, your lines can get tangled.